Lazio vs. Lecce (Sunday, 11.30am)
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After Lazio's resurgence continued with a midweek cup win over their arch-rivals, one of Serie A's form sides will now welcome Lecce to Stadio Olimpico on Sunday.
Having edged out Roma to make the Coppa Italia semi-finals, the Biancocelesti take on a club they have failed to beat in their last four attempts - including a shock loss on the opening day of this season.
We say: Lazio 2-0 Lecce
It is no coincidence that Lazio's improved form has arrived after re-finding last season's defensive steel. As Lecce often lack punch - particularly away from home - the home side should earn some revenge for their opening-day defeat.
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Cagliari vs. Bologna (Sunday, 2.00pm)
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Bologna make the trip to Sardinia on Sunday when they face Cagliari in Serie A, looking to keep their battle for a place in the top four going.
At the halfway stage of the season, there will be very different targets for the second half of the campaign for these two clubs.
We say: Cagliari 0-0 Bologna
Bologna's recent struggles have been there for all to see, and while goals have been hard to come by at the best of times, Zirkzee's absence will only enhance this problem.
Facing a side chasing the European places, any result will be a positive for Cagliari, who must now accept they are deep in a relegation battle, and the target will be to remain outside of the bottom three come the end of the weekend.
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Fiorentina vs. Udinese (Sunday, 5.00pm)
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Having booked their place in the Coppa Italia semi-finals, Fiorentina return to their pursuit of a top-six finish in Serie A when they host Udinese on Sunday.
In midweek, the Viola prevailed on penalties to progress in the cup, and they sat fourth in the standings at the halfway stage of the league season.
We say: Fiorentina 1-0 Udinese
As high-flying Fiorentina have been keeping things tight on home turf and Udinese have scored only six times on the road so far, the Viola should edge to victory by a single goal.
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AC Milan vs. Roma (Sunday, 7.45pm)
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Both knocked out of the Coppa Italia in midweek, Italian heavyweights AC Milan and Roma seek an immediate response when they meet at San Siro on Sunday evening.
Halfway through the league season, Milan lead their capital-city counterparts by 10 points in the Serie A standings, with either side targeting a top-four finish.
We say: AC Milan 2-1 Roma
Milan could complete the double over Roma in Serie A's Sunday night kickoff, as their squad has stood up to its latest raft of absences much better than their opponents, who are also depleted and are generally less effective outside of Rome.
