Orlando City vs. Chicago Fire (Saturday, 6.00pm)
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Chicago Fire will look to continue their unbeaten start to the Major League Soccer campaign when they take on Orlando City at Exploria Stadium this weekend.
The home side have struggled to click into gear so far this season and will be desperate to right their wrongs with a victory over high-flyers Chicago.
We say: Orlando City 0-2 Chicago Fire
A clash that is poised to be a decisive fixture even at this early stage of the campaign, an unbeaten Fire side will look to pounce on a stuttering Orlando.
Chicago have the firepower and the potential to blow the hosts away, with an away victory the most likely outcome.
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Inter Miami vs. New England (Saturday, 8.00pm)
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Inter Miami are still looking for their first win of the MLS season, after a draw on the opening day was followed up by four consecutive defeats, leaving them bottom of the Eastern Conference.
Saturday's visitors to the Lockhart Stadium have not been in much better form heading into this fixture, with New England Revolution aiming to end a four-game losing run across all competitions.
We say: Inter Miami 1-1 New England Revolution
With both teams entering this encounter in poor form, priority number one for Miami and the Revolution will be to not lose this game, which is why it is expected to be a tight affair.
New England have shown more promise in the attacking third than Miami so far this season, but the hosts will have home advantage which could help them gain a point this weekend.
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NY Red Bulls vs. Montreal (Saturday, 9.00pm)
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New York Red Bulls welcome Canadian outfit CF Montreal to the Red Bull Arena on Saturday, when the hosts could go top of the Eastern Conference having already collected 10 points from their first five matches.
Meanwhile, Montreal have endured a poor start to this year's MLS campaign, winning just once but that victory did come in their last outing which will be something the visitors will want to build on.
We say: New York Red Bulls 1-2 CF Montreal
New York have not been as good on their own patch as they have been away from home, and Montreal are in good scoring form which could give them the edge this weekend.
After netting seven goals in their last two games, which have both come on their travels, Montreal are certainly expected to get on the scoresheet a couple of times, and the Red Bulls may not be able to come up with enough of a response to rescue a point.
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Philadelphia vs. Columbus Crew (Saturday, 11.00pm)
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Philadelphia Union are looking to continue their unbeaten start to this year's MLS season when they welcome Columbus Crew to Subaru Park on Saturday.
The visitors are currently sitting fifth on eight points, five points behind league leaders Philadelphia, who could extend their lead at the top to six points if second and third place lose this weekend.
We say: Philadelphia Union 2-1 Columbus Crew
Philadelphia have kept three consecutive clean sheets, but Columbus are the highest scorers in the division at the moment, so the visitors are likely to find the back of the net on Saturday.
However, Union are in great form and will look to capitalise on the fact that Crew lost last weekend which may have knocked some of their confidence.
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LA Galaxy vs. Los Angeles (Sunday, 12.30am)
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Western Conference leaders Los Angeles FC make the short trip to Dignity Health Sports Park, where they will face rivals Los Angeles Galaxy on Sunday.
The visitors have put together an unbeaten run to begin this season, while LA Galaxy are not too far behind having picked up nine points from their first five matches.
We say: Los Angeles Galaxy 1-2 Los Angeles FC
Galaxy will be confident about getting on the scoresheet having netted three times last weekend, but their visitors arrive in good form and full of confidence.
Los Angeles FC have shown no signs as to why they will not come away with three points this weekend, and they are in better scoring form so should be able to outscore their hosts.
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Salt Lake vs. Toronto (Sunday, 1.00am)
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Toronto have an opportunity to win three games in a row for the first time since 2020 when they travel to Rio Tinto Stadium for a date with Real Salt Lake in Major League Soccer action on Saturday.
The Reds edged New York City FC to begin the month of April, their second consecutive 2-1 victory, while Claret and Cobalt could only manage a draw versus their arch-rivals, the Colorado Rapids.
We say: Real Salt Lake 2-1 Toronto
Toronto have put together a nice run of late and are showing definite improvement, but playing in the altitude of Salt Lake City against a side who have done a great job of making in-game adjustments will be a lot to handle.
The Reds have not won a game there since 2007, and we expect that streak will continue this weekend.
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Dallas vs. Colorado (Sunday, 1.30am)
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Dallas have an opportunity to match their longest unbeaten run from a year ago when they host the Colorado Rapids in Major League Soccer action on Saturday at Toyota Stadium.
The Toros have earned at least a point in three consecutive fixtures, while Colorado are also on a three-match unbeaten run, drawing their last two encounters by a 1-1 score.
We say: Dallas 0-1 Colorado Rapids
There are many things to like about the structure and shape that Dallas have played with so far this year, but Colorado are sharper defensively than we saw in their opener and have not conceded to the Toros in their last three encounters.
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Houston vs. Earthquakes (Sunday, 1.30am)
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Rooted to the bottom of the Western Conference, a stuttering San Jose Earthquakes outfit will look for their first win of the season when they visit Houston Dynamo this weekend.
The hosts are eyeing up a playoff berth come the end of the campaign and will be confident of piling the pressure onto the division's lowest-ranked side.
We say: Houston Dynamo 2-0 San Jose Earthquakes
Battling to climb up the table, San Jose look set for a long and arduous campaign in MLS.
On the other hand, Houston have shown signs of positivity so far and it could be another profitable afternoon for the Dynamo.
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Kansas vs. Nashville (Sunday, 1.30am)
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In a mid-table clash between two Western Conference sides hoping to climb the table, Nashville SC will make the journey to Sporting Kansas City on Saturday evening.
Having both experienced indifferent starts to the campaign, a victory could set one side on their way to a successful season, whereas further dropped points are likely to damage the others' hopes and ambitions.
We say: Sporting Kansas City 1-1 Nashville SC
Two teams that could do with a win to properly kick start their season, Sporting KC will be keen to use home advantage to get their noses out in front.
However, Nashville have shown in previous seasons they can be difficult to beat, and a score draw looks the most likely scenario in this fixture.
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Vancouver vs. Portland (Sunday, 3.00am)
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After winning their first match of the 2022 Major League Soccer regular season, the Vancouver Whitecaps now have a chance to extend their unbeaten run at BC Place Stadium to eight straight games when they host the Portland Timbers on Saturday.
Vancouver blanked Sporting Kansas City 1-0 last weekend, while the Timbers are winless in three straight fixtures, dropping a 3-1 decision versus the Los Angeles Galaxy to kick off the month of April.
We say: Vancouver Whitecaps 2-1 Portland Timbers
There is something about BC Place that seems to bring out the best in these Whitecaps, who have used that turf to their advantage.
We anticipate they will be able to expose a side in Portland who have struggled to close down the opposition's space in the final third, conceding 14 efforts on target and five goals in two road encounters this season.
